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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Vanillin, Fluorouracil
Phytochemical Name Vanillin (PubChem CID: 1183 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 436
Ref_1
Pair Name Vanillin, Fluorouracil
Disease Info [ICD-11: 2B91] Colorectal cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Up-regulation Phosphorylation MAP3K5 hsa4217
Up-regulation Phosphorylation MAPK14 hsa1432
Down-regulation Expression NNMT hsa4837
Up-regulation Cleavage PARP1 hsa142
Up-regulation Expression TP53 hsa7157
In Vitro Model HT-29 Colon adenocarcinoma Homo sapiens (Human) CVCL_0320
SW480 Colon adenocarcinoma Homo sapiens (Human) CVCL_0546
In Vivo Model A total of 3×10⁶ cells from each of the SW480/NC and SW480/NNMT cell lines were subcutaneously injected into nude mice (n=5 per cell line).
Result Vanillin is deemed to be a promising anticancer candidate by inhibiting NNMT and may attenuate NNMT‑induced resistance to 5‑Fu in human CRC therapy with few side effects.
03. Reference
No. Title Href
1 Vanillin downregulates NNMT and attenuates NNMT‑related resistance to 5‑fluorouracil via ROS‑induced cell apoptosis in colorectal cancer cells. Oncol Rep. 2021 Jun;45(6):110. doi: 10.3892/or.2021.8061. Click
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